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Thalidomide therapy for the treatment of hypertrophic herpes simplex virus-related genitalis in HIV-infected individuals.

Holmes A, McMenamin M, Mulcahy F, Bergin C

Department of Infectious Diseases, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA. andrea.m.e.holmes@uth.tmc.edu

Hypertrophic genital herpes is a disfiguring manifestation of a common infection seen in immunocompromised hosts that can be clinically mistaken for malignancy. We review the literature and describe hypertrophic genital herpes in a human immunodeficiency virus-positive patient receiving antiretroviral therapy. Treatment with valacyclovir, cidofovir, and foscarnet failed, but thalidomide treatment was successful.

Published 7 May 2007 in Clin Infect Dis, 44(11): e96-9.
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