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Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors.

Mugnaini C, Manetti F, Esté JA, Clotet-Codina I, Maga G, Cancio R, Botta M, Corelli F

Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via De Gasperi, 2 I-53100 Siena, Italy.

S-Aryl-S-DABO derivatives, a novel subclass of S-DABO anti-HIV-1 agents, were synthesized via Ullmann type reaction starting from the corresponding 2-thiouracils by the aid of microwave irradiation. The results of their evaluation as inhibitors of RT are reported together with their antiviral activity in cellular assays.

Published 1 June 2006 in Bioorg Med Chem Lett, 16(13): 3541-4.
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