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Variable benefit in neuropsychological function in HIV-infected HAART-treated patients.

Cysique LA, Maruff P, Brew BJ

Faculty of Medicine, St. Vincent's Clinical School, University of New South Wales, Sydney, Australia. lcysique@ucsd.edu

The authors examined cognitive performance change in 101 individuals with advanced HIV infection on highly active antiretroviral therapy (HAART), using standard neuropsychological testing in three visits, over a 27-month-period. Cognitive performance stabilized in a majority of HIV+ participants over time. A neuroactive HAART regimen was associated with neuropsychological improvement. Decline occurred in a minority with lower nadir CD4. The current CD4 count and plasma viral load were not associated with cognitive change.

Published 9 May 2006 in Neurology, 66(9): 1447-50.
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