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High seroprevalence of herpes simplex virus type 2 infection in French human immunodeficiency virus type 1-infected outpatients.

Andréoletti L, Piednoir E, Legoff J, Brodard V, Beguinot I, Strady C, Rouger C, Piketty C, Si-Mohamed A, Kazatchkine MD, Malkin JE, Bélec L

Unité de Virologie Médicale, Unité d'Hygiène Hospitalière et Service des Maladies Infectieuses, Hôpital Robert Debré, Centre Hospitalo-Universitaire de Reims, and IFR-53/EA-3798, Faculté de Médecine de Reims, Reims, France. landreoletti@chu-reims.fr.

Using commercially available herpes simplex virus (HSV) type-specific serological diagnostic tests, HSV type 2 (HSV-2) antibody prevalence was assessed in two parallel prospective studies including 534 human immunodeficiency virus type 1 (HIV-1)-infected outpatients living in two areas of northern France. In the first cohort of 434 subjects, 223 (51%) individuals demonstrated a positive HSV-2 serological status while 66 (66%) of 100 subjects in the second cohort were seropositive for HSV-2 (51 versus 66%; P = 0.08). Among the 223 HSV-2-seropositive subjects identified in the first study cohort, only 22 (10%) had suffered from recurrent anogenital lesions during the past 12 months while 154 (69%) had no clinical history of herpesvirus infection. Our findings demonstrate high proportions of subclinical and undiagnosed HSV-2 infection in HIV-1-infected individuals and suggest that HSV type-specific serological testing in the French HIV-1-infected subpopulation could be an efficient strategy to diagnose clinically asymptomatic HSV-2 infections.

Published 5 August 2005 in J Clin Microbiol, 43(8): 4215-7.
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